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elvitegravir/cobicistat/emtricitabine/tenofovir DF improves levels of bortezomib by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

nelfinavir will increase the stage or result of bortezomib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.

dronedarone will enhance the amount or outcome of bortezomib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.

Stay clear of utilizing the drug if liver enzymes improve to 2 to 3 moments the higher Restrict of ordinary. Assess for symptoms/symptoms of peripheral neuropathy. Regularly assess the amount standing and Look at orthostatic hypertension throughout the remedy. Purchase a baseline chest x-ray then periodic pulmonary functionality tests with new or worsening pulmonary symptoms.[13][14]

amobarbital will minimize the level or outcome of bortezomib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.

MedlinePlus Info on Bortezomib - A lay language summary of important information regarding this drug that may contain the next:

  The drug is administered parenterally and needs near checking through the nursing team. Apart from examining the CBC, the liver function involves assessment. Before beginning the drug, a baseline upper body X-ray is usually recommended.

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bortezomib will boost the stage or outcome of lonafarnib Vaborbactam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. If coadministration of lonafarnib (a sensitive CYP3A substrate) with weak CYP3A inhibitors is unavoidable, decrease to, or keep on lonafarnib at setting up dose.

Work out caution with grapefruit goods. Grapefruit inhibits CYP3A4 metabolism, which may boost the serum concentration of bortezomib.

To avoid this problem, get off the bed gradually, resting your ft on the ground for a couple of minutes just before CP-866087 standing up.

fedratinib will enhance the level 3'-cGAMP sodium or impact of bortezomib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on. Regulate dose of medication that happen to be CYP3A4 substrates as necessary.

Bortezomib provides a slim therapeutic window; an overdose can come about when doubling the dose. The affected person will usually present with marked thrombocytopenia and hypotension, that are very difficult to reverse.